The A180 is closed eastbound after an accident at the Brocklesby interchange.
A lorry has struck a car that was in a lay-by near the junction.
The road is now closed eastbound from the junction with the A160 to the A1173 Mathew Ford Way.
Motorists are being asked avoid the area if possible.
Traffic towards Grimsby is being affected by the road closure, and is being diverted towards South Killingholme along the A160.
Humberside Police have issued a short statement saying: “The A180 is currently closed eastbound from Brocklesby interchange to the A1173 off slip due to a road traffic collision. Motorists advised to avoid the area if possible.”
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